Structure of SARS-CoV-2 main protease (Mpro) in complex with nirmatrelvir (PF-07321332), new drug used to treat COVID-19.
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Effective treatments for Covid-19 have not yet been identified, but earlier experience with SARS and MERS has led to trials of existing agents, including lopinavir, an HIV-1 aspartate protease inhibitor, and ritonavir, added to increase the half-life of lopinivir by inhibiting cytochrome P450. New research findings are summarized in a short video. #COVID19 #SARSCoV2 https://nej.md/2VUqDuC | The New England Journal of Medicine
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