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If you started anastrozole, letrozole, exemestane, or tamoxifen and suddenly feel older, stiffer, weaker, or weirdly injury-prone, you are not crazy, and you are not imagining it. I see this pattern all the time in chronic pain and post-treatment cases. These medications change hormone signaling. Aromatase inhibitors lower estrogen much more aggressively than tamoxifen, which is why the classic AIMSS pattern is usually stronger with AIs. In some people that shows up as morning hand stiffness, we
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