Things Women Should Keep an Eye On Noticing changes early helps catch infections and hormone-related conditions before they worsen. 💥 Painful sores or blisters on vulva → may be herpes or syphilis Herpes causes clusters of painful fluid-filled blisters that crust and heal, often recurring with burning or tingling. It’s due to HSV-1 or HSV-2. In contrast, syphilis presents as a single, firm, painless ulcer (chancre) that can go unnoticed until secondary symptoms appear. Both need prompt testing