Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and ...

Background Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead ...

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide, reflecting the growing prevalence of obesity and type 2 diabetes. Some patients ...

1 Department of Upper Gastro-intestinal Surgery, Hope Hospital, Salford Royal Hospitals NHS Trust, Manchester, UK 2 Department of Pathology, Hope Hospital, Salford Royal Hospitals NHS Trust, ...

Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, the regulatory effect of CXCL8 on immune ...

The GI tract is colonised by trillions of bacteria in a complex community collectively referred to as the gut microbiota. This metabolically active ‘foreign’ body contributes to host metabolism and ...

1 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK 2 Histopathology Unit, Cancer Research UK, Lincoln’s Inn Fields, London, UK and Molecular Pathology Centre, Institute of ...

Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK Dr A Walther, Molecular and Population Genetics, London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London ...

Department of Veterans Affairs Medical Centre, University of New Mexico, Albuquerque, New Mexico, USA Dr A Sonnenberg, Department of Veterans Affairs Medical Centre 111F, 1501 San Pedro Drive SE, ...

4 Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia Correspondence to Dr Hashem B El-Serag, Section of Gastroenterology and ...