The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

The San Francisco 49ers' season has been on the brink for weeks, and the Week 13 blowout loss to the Buffalo Bills certainly ...

The injury news for the San Francisco 49ers was twice as bad as expected Monday. Running back Christian McCaffrey will go on ...

Dec 1, 2024; Orchard Park, New York, USA; San Francisco 49ers quarterback Brock Purdy (13) after the game against the Buffalo ...

The San Francisco 49ers hosted a fan-focused event with the 49ers Pride Fan Group and PLUS (LGBTQ+) ERG to discuss being out ...

The disastrous season for the San Francisco 49ers continued Monday with word of both the team's top running backs out for ...

The San Francisco 49ers suffered another crushing defeat, this time in a snowy showdown against the Buffalo Bills. The 35-10 ...

Lake effect snow is slamming the Great Lakes, with seven states from Wisconsin to New York under snow alerts on Monday. In ...

One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

Buffalo's Allen became the first quarterback ever to score touchdowns running, passing and receiving in a single game.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...