When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle Seahawks, it called the very fate of the San Francisco 49ers 2024 NFL season into question.

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock Purdy. Backup quarterback Brandon

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with potentially 2-3 feet of additional

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five keys to victory for the Bills as they welcome the 49ers into Orchard Park,

The Buffalo Bills played the Kansas City Chiefs in their last game before heading into the bye week. They pulled off the upset and handed the Chiefs their first loss of the 2024 NFL season by a score of 30-21.

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San Francisco 49ers. Buffalo's fresh off a bye following a statement win against the two-time defending champion Kansas City Chiefs.

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management appears to be starting an end-of-year cleanup and has let