Computational models of the glucoregulatory system constitute a powerful tool for preclinical evaluation and mechanistic insight into therapeutics. However, in the case of diabetes, there is a dearth ...

Major challenges remain to precisely detect low-abundance proteins rapidly and cost-effectively from diverse biofluids. Here, we present a gold nanoparticle (AuNP)-supported, rapid electronic ...

l-Serine, a nonessential amino acid in humans, possesses significant physiological functions and is widely used in the food, cosmetic, and pharmaceutical industries. Driven by steadily growing market ...

The high clinical failure rate of small-molecule drugs is inarguably attributable to the lack of reliable predictions of chemical structure–efficacy–toxicity relationships that are applicable to ...

Low loose bulk density, a characteristic commonly observed in large accumulations of needle-like crystals, has caused numerous issues in both production processes and daily life. Antisolvent ...

Sluggish reaction kinetics and severe dendrite growth are two main obstacles that hinder lithium–sulfur batteries (LSBs) from practical applications. Here, unconventionally d–p hybridized ...

The total synthesis of two monoterpenoid indole alkaloids (MIAs), erchinines A and B, is described. Isolated from the plant Ervatamia chinensis, both compounds display antimicrobial activity against ...

Werner syndrome (WS) is an autosomal recessive disorder caused by mutations in the Werner syndrome protein (WRN, also known as RecQ3) gene. As a pivotal member of the RecQ DNA helicase family, WRN ...

Simultaneous construction of two new C–C bonds in the alkene substrates regioselectively is significantly challenging. Herein, we report an unprecedented regioselective arylcarboxylation strategy of ...

We have developed a copper-catalyzed formal aldehydic C–H borylation using a neutral sp2–sp3 diboron reagent, LBH2–Bpin (where L is a σ-donor), leading to the one-pot synthesis of diverse acylboranes.

mRNA therapy holds significant promise for preventing and treating diverse diseases. The development of safe and effective cationic polymers for mRNA delivery is essential for advancing its clinical ...

Ti-deficient TiO2 nanosheets derived from lepidocrocite-type titanate delamination show a p-type conductivity with a band gap widened by the quantum confinement effect to 3.7 eV. This shift in the ...