San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

The Pittsburgh Steelers and Cleveland Browns had one of the most picturesque games in NFL history last Thursday night when ...

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.