They will head out on the road to face off against the Arizona Cardinals at 4:05 p.m. ET at State Farm Stadium. The 49ers will be looking to extend their current five-game winning streak. Last Sunday, ...

The San Francisco 49ers on Monday opened the practice window for second-year safety Malik Mustapha. Mustapha was participating in the individual portion of Monday's bonus practice for the 49ers ...

The San Francisco 49ers opened Week 5 with a victory over the Los Angeles Rams on Thursday Night Football. They got another win Sunday when the rest of the NFC West and the lone remaining undefeated ...

Hall of Fame quarterback Peyton Manning and former NFL quarterback Eli Manning are joined by San Francisco 49ers linebacker Fred Warner as they react to Jacksonville Jaguars quarterback Trevor ...