Depending on the exact problem, you may be able to fix the issue by using another USB port, or getting a new USB dongle or adapter. How to fix wireless mouse keeps disconnecting issue?

If your USB or wireless peripherals stop responding on connecting USB Flash Drive, it may be interference or Power Management issue. Here's the fix.

If your keyboard or mouse not working in Safe Mode, the problem may be with the respective device drivers. Use these fixes to resolve the issue.

He had a wireless usb mouse, and it quit working. However, a PS/2 mouse would work just fine.<BR><BR>After attempting nearly everything to get the mouse working again, I purchased a second mouse.