The Road to 272 Bets was never going to be a profitable venture when I started doing it six years ago. Professional bettors don't bet on every single NFL game,

In Sporting News' Week 16 picks against the spread, Detroit and Green Bay rebound from tough losses while the Chargers, Broncos and Chiefs all win in the AFC West.

NFL Week 15 is here and we asked USA TODAY Sports' staff for their top bets for the entire NFL slate. Here are their picks and predictions.

The Carolina Panthers failed to take care of business back in Week 10, during their first matchup with the New Orleans Saints. Despite pulling off one of the biggest upsets of the campaign the Sunday prior in Green Bay, they came up flat against their division rivals—dragging along to a disappointing 17-7 loss.

This week in the NFL, we get a rematch of Bills vs. New England Patriots, Jordan Love travels to take on one of the best defenses in the NFL in the Denver Broncos, while the " Matthew Stafford Bowl" takes place in Los Angeles.

There are some juicy matchups this weekend, many with playoff implications for the league's top teams. But no one is more desperate than Kansas City.

Each week Jeff Schudel makes his NFL picks against the Las Vegas betting line while picking the Browns score separately. Picks are in bold letters. Last week: 8-4. Overall: 84-93-2. Browns vs.

More than one team beat the odds in Week 15 of the 2025 NFL season. Find out more about those underdogs who came out on top in the article below. FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.