Mitochondrial Targeting: The introduction of a mitochondrial matrix targeting sequence results in mt-TurCaMPb, which is tailored for the specific detection of calcium elevations within mitochondria.

Cancer cells provide healthy neighboring cells with additional mitochondria to put them to work. This has been demonstrated by researchers at ETH Zurich in a new study. In this way, cancer is ...

Cancer cells provide healthy neighbouring cells with additional cell powerhouses to put them to work. This has been demonstrated by researchers at ETH Zurich in a new study. In this way, cancer is ...

“The mitochondrial pyruvate carrier (MPC) is responsible for transporting pyruvate, produced from sugars by glycolysis in the cytosol, into the mitochondrial matrix,” the authors explained.

 (1) Degradation of mitochondria matrix, inner membrane and intermembrane oxidised or misfolded protein by mitochondrial proteases. (2) Ubiquitinated outer mitochondrial membrane proteins are ...

Further experiments pieced together the molecular pathways involved. In a nutshell, the authors found that neuronal activation induces the phosphorylation of the mitochondrial calcium uniporter by ...

This shows that (a) NADP+ is taken up by the mitochondria across the inner membrane and into the matrix, and (b) NADP+-reducing activities of malate dehydrogenase and the NADP+-specific isocitrate ...

Mitochondria are specialized structures within cells that are primarily responsible for energy production but that also play a key role in how cells respond and adapt to stress. When their ...