Despite the widespread adoption of antiretroviral therapy (ART), HIV infection remains a global pandemic with more than 40 million people are currently infected. While treatment for HIV has greatly ...

Researchers at the University of Washington and Fred Hutch found that CARD8, an inflammasome sensor, detects HIV-1 in macrophages during cell-to-cell viral transmissions from infected T cells. HIV can ...

Addressing the question of whether and how immune cells (macrophages) in the central nervous system (CNS) traffic out, researchers have now identified a perineural pathway through which the HIV virus ...

Groundbreaking study in The American Journal of Pathology reveals how infected immune cells travel from the brain through the body, potentially reseeding HIV and sustaining inflammation The CNS has ...

As part of the body's first line of defense against foreign invaders, macrophages play an integral role in the innate immune ...