Bethesda, MD - Scientists have discovered a DNA sequence that is involved in controlling the timing of DNA replication. Because alterations in DNA replication timing are associated with cancer ...

Such studies should flourish now that the team has shown that "all you need to do to study replication timing is grow cells and sequence their DNA, which everyone is doing these days," said Koren.

Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

Mistakes made during DNA replication can lead to mutations—permanent alterations in the DNA sequence that can have varying effects on the organism, ranging from benign to harmful.

Study finds DNA replication timing varies among people.

The whole DNA molecule is colored blue and the green tick marks are landmarks—or specific sequences of DNA that occur on average every 4,500 base pairs.

This Review presents a quantitative framework for translating DNA sequences into transcriptional behaviours. Such a model, based on the binding affinity landscape of molecules to genomic sequences ...

DNA replication begins when the double helix, caught in a vice of proteins, melts, scientists have discovered.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

Malgorzata Bzymek, Susan T. Lovett, Instability of Repetitive DNA Sequences: The Role of Replication in Multiple Mechanisms, Proceedings of the National Academy of Sciences of the United States of ...