The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice.

Cre-Controlled CRISPR, the new method developed by a team of Dresden researchers led by Prof. Michael Brand, combines the benefits of the Cre/lox system with the CRISPR/Cas9 genetic scissors.

Extensive research has demonstrated the immense potential of the site-specific recombinase Cre-Lox system for precise chromosomal manipulation.

Macarena Fernández-Chacón says that "the use of this new genetic tool will significantly change research projects that depend on the Cre-lox system, because now we can see and be confident about ...

Transgenic progeny from one of these lines can be induced to develop T-ALL by injecting Cre RNA into one-cell-stage embryos, demonstrating the utility of the Cre/lox system in the zebrafish and ...