This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the ...

Fluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription. In steady state, the ...

Transcription dynamics in the context of DNA damage response encompass the interactions between RNA polymerases and lesions within the DNA template, the resulting impact on transcriptional continuity, ...

Water molecules play an active, essential role in gene transcription, helping RNA polymerase II carry out the chemical steps needed to read DNA and build RNA. Researchers have uncovered a previously ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, ...

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

An international research team led by Forschungszentrum Jülich and the IPK Leibniz Institute has developed an artificial ...

The human heart must constantly adapt to changing demands—a task that requires tightly coordinated molecular shuffling in ...