To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send ...

Deregulated pyrimidine metabolism (PyMet) contributes to various tumorigenic features of cancer, including chemoresistance and epithelial-to-mesenchymal transition. However, cancer often encompasses ...

Signal transduction The cellular process that converts a signal, such as a hormone, growth factor, neurotransmitter, cytokine, mechanical force, or environmental cue, into biochemical changes inside ...

Pulmonary hypertension (PH) is a global health issue characterized by high mortality. The main targets for current therapies in PH focus on the prostacyclin, nitric oxide, and endothelin pathways.

Melatonin reduced infection-related inflammation in human fetal membranes in an ex vivo model. The study suggests that this ...

An international study led by a scientist at the University of Ottawa Faculty of Medicine is opening new frontiers in the ...

BPC-157 and TB-500, originating from gastric and thymic sources respectively, both influence angiogenesis, cytoskeletal ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...

A new study has uncovered a key mechanism that helps one of the deadliest brain cancers evade the immune system, according to ...

Neuroinflammation is now recognized as a central driver instead of being merely a consequence of many neurological diseases, including neurodegenerative ...