Cysteine-rich secretory proteins (CRISPs) constitute a family of secreted proteins predominantly produced in the male reproductive tract. These proteins have been implicated in a range of processes ...

A novel reporter protein has been developed to enable the investigation of protein biogenesis in the ER and its disruption in disease. A recent research collaboration between multiple Japanese ...

Osaka, Japan – Our cells carry out hundreds of thousands of important functions every day, all of which are carefully orchestrated at a microscopic scale. However, the precise mechanisms that ...

How does the ER prevent misfolded proteins? Researchers identify the SLC33A1 transporter as a critical glutathione regulator ...

A multi-institutional team led by the Chinese Academy of Sciences has constructed a proteomic atlas of human aging across 13 organs, revealing tissue-specific aging clocks, transcriptome-proteome ...

While companies developing drugs to treat Alzheimer's disease have spent decades and many billions of dollars targeting amyloid beta due to its role in clogging patients' brains with harmful deposits, ...