The receptor activator of nuclear factor-κB ligand (RANKL) and its receptor RANK constitute a central axis in the regulation of bone remodelling and metastatic spread. In healthy bone, RANKL produced ...

A well-known bone-removal pathway can operate in reverse to stimulate bone production, a Japan-led team has discovered. This finding could lead to new therapies for osteoporosis and other skeletal ...

It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its ...

Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

An evaluation of bone marrow stromal-derived growth factor-1 and interleukin-8 levels in patients with stage I-III breast cancer with disseminated tumor cells. This is an ASCO Meeting Abstract from ...

Drinking milk helps your bones grow big and strong, but what if direct exposure to light could help, too? Now, researchers from Japan report that lighting up bone tissue could help treat bone disease.

Association of Ki-67 expression in CTCs with disease relapse in patients with early breast cancer (BC) and affect by the administration of adjuvant chemotherapy. This is an ASCO Meeting Abstract from ...