To trap the primed actomyosin complex, we pre-incubated a myosin-5 construct (motor domain plus one IQ light chain-binding domain) with ATP for about 2 s, allowing the myosin to bind and hydrolyse ATP ...

Researchers have characterized changes in the structure of motor proteins, called myosins, and energy consumption that occur during hibernation, highlighting key differences in large and small ...

Hypertrophic cardiomyopathy (HCM) is an inherited disease of the sarcomere resulting in excessive cardiac contractility. The first-in-class cardiac myosin inhibitor, mavacamten, improves symptoms in ...