Medical Xpress

Study discovers protein implicated in Batten disease is critical for generating new lysosomes

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, ...
News Medical

Study provides insights into the molecular mechanism of Batten disease

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, ...
Nature

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

Macroautophagy, which is conserved from yeast to humans, is a process whereby cells capture typically cytoplasmic material in double-membraned autophagosomes (Box 1) and then traffic these organelles ...
EurekAlert!

New insights: a natural small molecule isowalsuranolide targeting TrxR1/2 and triggering self-eating (autophagy) to combat cancer

Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
Nature

Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway

Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we found that advanced oxidation protein products (AOPPs) ...