Leptin is a cell-signalling hormone vital in the regulation of appetite, food intake and body weight. Studies have shown that an absence of leptin in the body or leptin resistance can lead to ...

The energy-regulating hormone leptin affects signals emerging from certain brain regions. New results explore the nature of these signals, finding a central role for phosphoinositide-3 kinase in the ...

Typically, when PD is diagnosed, half of the dopaminergic axons and neurons within the substantia nigra pars compacta are already lost. Thus, there is an urgent need to identify early PD markers. The ...

Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults in Korea. Lower baseline leptin was associated with a greater increase in tau over 2 ...

In a new study, Yale researchers offer insight into leptin, a hormone that plays a key role in appetite, overeating, and obesity. Their findings advance knowledge about leptin and weight gain, and ...

The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic ...

Leptin reduces food intake in part by enhancing satiety responses to gastrointestinal signals produced in response to food consumption. Glucagon-like peptide 1 (GLP-1), secreted by the intestine when ...

Twenty years after the hormone leptin was found to regulate metabolism, appetite, and weight through brain cells called neurons, Yale School of Medicine researchers have found that the hormone also ...

A long run feels the worst until it feels the best. That's primarily thanks to the runner's high -- those euphoric feelings that strike halfway through an endurance workout. Now, researchers have ...