Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...
Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...
Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for ...
Efficient and accurate DNA replication is essential for the preservation and transmission of the genetic information of all living organisms, from bacteria to humans. However, DNA replication shares ...
Genome integrity is critical for cell homeostasis, an equilibrium that is challenged by DNA damage. Among the >50,000 DNA lesions per day produced in a human cell, the most abundant are abasic (Ap) ...
A recent study in Nature Communications examined how RNA polymerase I (Pol I) responds to abasic (Ap) site formation—the most common type of DNA damage. The researchers found that Pol I helps maintain ...
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