New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the cell. A team led by Penn ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Matthew Gage, Ph.D., Department of Chemistry, University of Massachusetts Lowell Juan Artes Vivancos, Ph.D., Department of Chemistry, University of Massachusetts ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.

The primary rationale for middle-down proteomics is the need for high-confidence proteoform analysis that is also scalable. A proteoform is defined by its full complement of modifications and sequence ...