Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

Guanine-rich DNAs can fold into noncanonical DNA structures called G-quadruplexes (G4s). G4s are formed by the stacking of several G-tetrads, each of which consists of four guanine bases held together ...

Researchers led by University of Tsukuba have discovered rdxPolA, a putative DNA polymerase involved in replicating ancestral mitochondrial genomes, in diverse eukaryotic lineages. Based on the ...

Translesion DNA synthesis (TLS) is a specialised branch of the DNA damage tolerance pathway that enables eukaryotic cells to replicate past lesions that would otherwise stall the replication machinery ...