Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend on the ability of chromatin—a mix of DNA and ...

On the left is a snapshot of single histone molecules (red) inside a cell nucleus (dotted line). On the right, we see the trajectories of these molecules’ movement over time. The colors show the path ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, determines which genetic instructions are activated. When this fails, the wrong ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

An unexpected lab observation has led a team of scientists to discover how diet can influence survival in animal models of ...

We were delighted to have had the chance to sit down with Cigall Kadoch, Professor at the Dana-Farber Cancer Institute ...

Dr. Yasuhiro Arimura studies chromatin, the mixture of DNA and DNA-packaging proteins. Chromatin is “marked” with numerous chemical or structural cues that enable cells to organize DNA and manage how ...