Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...
The quantification of proteins is an integral part of biopharmaceutical R&D. From the crude quantitation of hybridoma expression profiles of monoclonal antibodies, to quantitative determination of ...
To choose the best lead candidates during drug and antibody screening, scientists characterize a molecule’s binding properties, such as kinetics and affinity. Robust assay design reduces experimental ...
How to use this book / David Wild -- Immunoassay for beginners / David Wild -- Immunoassay performance measures / Chris Davies -- Principles of competitive and immunometric assays (including ELISA) / ...
Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can ...
Analytical testing for biologics is evolving rapidly as new protocols become available and companies seek to expedite current methodologies. This article offers expert insight into bioassays and ...
The early identification of antibody candidates with desired affinities and dissociation kinetics, binding epitopes and critical quality attributes is vital for avoiding later-phase failures caused by ...
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