Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...

Scientists may have finally found a way to safely restore AMPK function in humans, a milestone many researchers in the aging biology field have pursued for almost 30 years. In a release on Monday, ...

Activating the PPARβ/δ-AMPK metabolic pathway could be an effective strategy to tackle the most common chronic liver disease in the world’s population. A study led by Manuel Vázquez Carrera, group ...

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in organ development. Although SOX9 has been implicated in regulating lipid ...

Dose-optimization data from the Phase 1 study expected Q3 2026 to support Phase 2 proof-of-concept initiation in ADPKD in Q4 2026JERSEY CITY, N.J., June 30, 2026 (GLOBE NEWSWIRE) -- SCYNEXIS, Inc.