Undefeated Buffalo (4-0) faces New England (2-2) at Highmark Stadium with kickoff set for 8:20 p.m. ET on NBC, with streaming options available on multiple platforms.

The Bills dropped an ugly game against the Patriots on Sunday Night Football. These players are most to blame for that crushing L.

The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 49.

The Patriots are just a game behind the Bills in the AFC East with a valuable head-to-head road win over Buffalo in hand.

The Patriots and the Bills kick off Sunday, October 5 at 8:20 p.m. ET. The game will be broadcast live on NBC and Peacock. As always with Sunday Night Football broadcasts, the game will be preceded by Football Night in America, recapping the day's action and looking ahead to key stories and matchups in the Sunday Night Football game of the week.

Sunday Night Football in NFL Week 5 features the New England Patriots traveling to the Buffalo Bills tonight. SNF start time, NFL schedule and how to watch.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.