San Francisco 49ers wide receiver Brandon Aiyuk is likely itching to get back on the field after suffering a season-ending injury in Week 7 last season, but he and the team may have broken an NFL rule as he works his way back from a torn ACL and MCL.

Tyree Wilson made a handful of plays against the San Francisco 49ers that he has never made his entire NFL career originally appeared on A to Z Sports. We all know how big of a year this is for Tyree Wilson, the Las Vegas Raiders ' former No. 7 overall pick a few years ago. This, in many ways, can be a make it or break it season.

For a moment during Saturday's preseason game against the Las Vegas Raiders, it seemed as if the San Francisco 49ers had turned back the clock with an Owens streaking through the opposing secondary.

The San Francisco 49ers will face the Las Vegas Raiders in week 2 of the NFL preseason on Saturday at Allegiant Stadium.

The San Francisco 49ers lost starting right guard Dominic Puni and two other offensive players in the first half of their 22-19 preseason win over the Las Vegas Raiders.

For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

Today's Raiders-49ers game featured an iconic name in San Francisco franchise history recording his first reception.

Several big-name NFL players are under pressure this season, with their futures and their teams' success on the line. New York Jets quarterback Justin Fields is on his third team in five

Here is where the San Francisco 49ers rank among the top-10 most valuable franchises in the NFL, per Sportico’s latest valuations.

Las Vegas Raiders rookie running back Ashton Jeanty ran over a San Francisco 49ers defender in a highlight-reel moment in his second preseason game.