Southern Illinois University Edwardsville is a public university in Edwardsville, Illinois, United States. Located within the Metro East of Greater St. Louis, SIUE was established in 1957 as an extension of Southern Illinois University Carbondale. It is the younger of the two major institutions of Southern Illinois University system. SIUE has eight con…Southern Illinois University Edwardsville is a public university in Edwardsville, Illinois, United States. Located within the Metro East of Greater St. Louis, SIUE was established in 1957 as an extension of Southern Illinois University Carbondale. It is the younger of the two major institutions of Southern Illinois University system. SIUE has eight constituent undergraduate and graduate colleges, including those in arts and sciences, business, dentistry, education, engineering, graduate study, nursing, and pharmacy, in addition to the East St. Louis Center.